Research Library
A dossier-led catalogue of compounds, therapies, and interventions organized by confidence, biomarker linkage, and literature recency so users can get into the evidence quickly.
Coverage
Compounds mapped
13
Canonical dossiers available for live research review.
Biomarkers
Biomarker-linked entries
13
Entries with human-linked marker coverage users can actually act on.
Claims
Evidence-graded signals
1124
Signals with explicit grading rather than unsupported promise language.
Literature
Literature-tracked entries
13
Research objects with enough study depth or recency to review with confidence.
Query the library
Search across compound aliases, subtitles, and taglines before narrowing by section.
Signals worth reviewing now
Curated research desk
Start with the most decision-useful dossiers, then drop into the full catalogue once you know which part of the evidence base deserves real attention.
Highest confidence
Creatine
Evidence index
95
High confidence with 925 tracked studies. Best matched for recovery.
Why this matters now
Start here when you want the fastest route into the part of the library that is most likely to influence an actual decision, not just add more reading.
Direct dossier path
Open dossierFreshest literature
NAC
Latest RCT
2026
Current through 2026. AST is the clearest linked biomarker.
Direct dossier path
Open dossierRich dossier map
Magnesium
Linked biomarkers
124
124 linked biomarkers and 124 graded signals with richer dossier coverage.
Direct dossier path
Open dossierFull catalogue
Search the full research stack
Featured intelligence helps orient the review. This section is for the deeper sweep once you know which category, compound, or dossier thread deserves time.
Resistance Training
Progressive Overload Protocol
Strongest lifestyle intervention for metabolic and hormonal biomarker optimisation
Protocol signal
3-5×/week / 45-60 min/session
- Best for
- Metabolic
- Top biomarker
- Hba1c
- Literature
- Deep literature base
- Coverage
- 6 graded signals
- Evidence grade
- A
- Linked biomarkers
- 6
- Tracked studies
- 340
Zone 2 Cardio
Aerobic Base Training (60–70% max HR)
Gold standard for cardiovascular health and mitochondrial biogenesis
Protocol signal
3-5×/week / 45-90 min/session
- Best for
- Cardiovascular
- Top biomarker
- Triglycerides
- Literature
- Deep literature base
- Coverage
- 6 graded signals
- Evidence grade
- A
- Linked biomarkers
- 6
- Tracked studies
- 280
HIIT
High-Intensity Interval Training
Time-efficient protocol with superior metabolic outcomes per training hour vs steady-state
Protocol signal
2-3×/week / 20-30 min/session
- Best for
- Cardiovascular
- Top biomarker
- Hba1c
- Literature
- Active literature base
- Coverage
- 5 graded signals
- Evidence grade
- A
- Linked biomarkers
- 5
- Tracked studies
- 185
Sleep Optimisation
7–9 Hours · Consistent Circadian Schedule
Most impactful recovery intervention; poor sleep dysregulates cortisol, testosterone, and glucose
Protocol signal
7-9 hours/night / Consistent schedule
- Best for
- Sleep
- Top biomarker
- Cortisol
- Literature
- Deep literature base
- Coverage
- 5 graded signals
- Evidence grade
- A
- Linked biomarkers
- 5
- Tracked studies
- 220
Protein Adequacy
Target Intake & Distribution (0.7–1g/lb)
Prerequisite for hormone synthesis, muscle preservation, and IGF-1 signalling
Protocol signal
0.7-1g/lb daily / Distributed across meals
- Best for
- Hormonal
- Top biomarker
- Igf 1
- Literature
- Deep literature base
- Coverage
- 4 graded signals
- Evidence grade
- A
- Linked biomarkers
- 4
- Tracked studies
- 310
Creatine
Monohydrate
Strength · Cognitive performance
Mechanism signal
Phosphocreatine (PCr) acts as a rapid phosphate buffer via creatine kinase (CK), regenerating ATP from ADP during high-intensity muscle contraction and extending time to fatigue by maintaining cytosolic phosphorylation potential.
- Best for
- Recovery
- Top biomarker
- AST
- Literature
- Current through 2026
- Coverage
- 96 graded signals
- Evidence index
- 95
- Linked biomarkers
- 99
- Tracked studies
- 925
NAC
N-Acetyl Cysteine
Liver protection · Glutathione synthesis
Mechanism signal
Glutathione precursor — rate-limiting cysteine donor for de novo GSH synthesis via γ-glutamylcysteine synthetase
- Best for
- Hepatic
- Top biomarker
- AST
- Literature
- Current through 2026
- Coverage
- 130 graded signals
- Evidence index
- 91
- Linked biomarkers
- 131
- Tracked studies
- 925
Omega 3
EPA + DHA
Triglycerides · Inflammation · CV risk
Mechanism signal
Hepatic VLDL-TG synthesis suppression via reduced SREBP-1c and diacylglycerol acyltransferase activity; increased beta-oxidation via PPARα activation
- Best for
- Cardiovascular
- Top biomarker
- TG
- Literature
- Current through 2026
- Coverage
- 152 graded signals
- Evidence index
- 89
- Linked biomarkers
- 121
- Tracked studies
- 925
Magnesium
Glycinate and L-Threonate
Insulin sensitivity, sleep, and muscle function
Mechanism signal
Insulin signaling — insulin receptor tyrosine kinase cofactor
- Best for
- Sleep
- Top biomarker
- Magnesium
- Literature
- Current through 2026
- Coverage
- 124 graded signals
- Evidence index
- 88
- Linked biomarkers
- 124
- Tracked studies
- 925
Ubiquinol
Reduced CoQ10
Mitochondrial electron transport & antioxidant defence
Mechanism signal
Mitochondrial electron transport chain cofactor — ubiquinol shuttles electrons from Complex I (NADH-CoQ reductase) and Complex II (succinate-CoQ reductase) to Complex III (cytochrome bc1) via the Q-cycle, enabling oxidative phosphorylation and ATP generation; ubiquinol is the active reduced form that donates electrons at the Qo site of Complex III
- Best for
- Mitochondrial
- Top biomarker
- AST
- Literature
- Current through 2026
- Coverage
- 68 graded signals
- Evidence index
- 87
- Linked biomarkers
- 68
- Tracked studies
- 186
Berberine
HCl Extract
Blood glucose · LDL · Gut microbiome
Mechanism signal
KCNH6 voltage-gated K⁺ channel blockade → accelerated channel inactivation → prolonged β-cell action potential → Ca²⁺ influx via VGCCs → glucose-dependent insulin secretion
- Best for
- Metabolic
- Top biomarker
- TG
- Literature
- Current through 2026
- Coverage
- 70 graded signals
- Evidence index
- 84
- Linked biomarkers
- 75
- Tracked studies
- 262
L Theanine
Free amino acid
Alpha-wave support · calm focus · sleep quality
Mechanism signal
Glutamate receptor antagonism — L-theanine binds AMPA, kainate, and partially antagonizes NMDA glutamate receptor subtypes, inhibiting excitatory neurotransmission; structurally analogous to glutamate and inhibits glutamine re-uptake at pre-synapse, reducing glutamate pool replenishment
- Best for
- Sleep
- Top biomarker
- ALP
- Literature
- Current through 2026
- Coverage
- 58 graded signals
- Evidence index
- 82
- Linked biomarkers
- 58
- Tracked studies
- 107
PCSK9 Inhibitors
Monoclonal Antibodies (Evolocumab / Alirocumab)
- Best for
- Lipid Lowering
- Top biomarker
- Awaiting dossier
- Literature
- Awaiting dossier sync
- Coverage
- Registry preview
- Evidence index
- 80
- Linked biomarkers
- Preview
- Tracked studies
- Preview
GLP-1 Agonists
Incretin Mimetics (Semaglutide / Liraglutide)
- Best for
- Glycemic Control
- Top biomarker
- Awaiting dossier
- Literature
- Awaiting dossier sync
- Coverage
- Registry preview
- Evidence index
- 80
- Linked biomarkers
- Preview
- Tracked studies
- Preview
Levothyroxine
Synthetic T4 Thyroid Hormone
- Best for
- Thyroid
- Top biomarker
- Awaiting dossier
- Literature
- Awaiting dossier sync
- Coverage
- Registry preview
- Evidence index
- 80
- Linked biomarkers
- Preview
- Tracked studies
- Preview
Proton Pump Inhibitors
H+/K+-ATPase Inhibitors (Omeprazole / Pantoprazole)
- Best for
- Gastrointestinal
- Top biomarker
- Awaiting dossier
- Literature
- Awaiting dossier sync
- Coverage
- Registry preview
- Evidence index
- 80
- Linked biomarkers
- Preview
- Tracked studies
- Preview
Statins
HMG-CoA Reductase Inhibitors
- Best for
- Lipid Lowering
- Top biomarker
- Awaiting dossier
- Literature
- Awaiting dossier sync
- Coverage
- Registry preview
- Evidence index
- 80
- Linked biomarkers
- Preview
- Tracked studies
- Preview
Metformin
Biguanide Antidiabetic
- Best for
- Glycemic Control
- Top biomarker
- Awaiting dossier
- Literature
- Awaiting dossier sync
- Coverage
- Registry preview
- Evidence index
- 80
- Linked biomarkers
- Preview
- Tracked studies
- Preview
Fibrates
PPARα Agonists
- Best for
- Lipid Lowering
- Top biomarker
- Awaiting dossier
- Literature
- Awaiting dossier sync
- Coverage
- Registry preview
- Evidence index
- 80
- Linked biomarkers
- Preview
- Tracked studies
- Preview
Niacin (Rx)
Extended-Release Niacin
- Best for
- Lipid Lowering
- Top biomarker
- Awaiting dossier
- Literature
- Awaiting dossier sync
- Coverage
- Registry preview
- Evidence index
- 80
- Linked biomarkers
- Preview
- Tracked studies
- Preview
Ezetimibe
Cholesterol Absorption Inhibitor
- Best for
- Lipid Lowering
- Top biomarker
- Awaiting dossier
- Literature
- Awaiting dossier sync
- Coverage
- Registry preview
- Evidence index
- 80
- Linked biomarkers
- Preview
- Tracked studies
- Preview
Finnish Sauna
Dry Heat Exposure (80–100°C)
4×/week sauna associated with 40% reduction in CVD mortality across 20-year Kuopio cohort
Protocol signal
3-4×/week / 15-20 min at 80-100°C
- Best for
- Cardiovascular
- Top biomarker
- Hscrp
- Literature
- Targeted literature base
- Coverage
- 3 graded signals
- Evidence grade
- B
- Linked biomarkers
- 3
- Tracked studies
- 48
Cold Water Immersion
Deliberate Cold Exposure (≤15°C)
Strong acute norepinephrine release; emerging evidence for inflammatory and metabolic benefits
Protocol signal
3-5×/week / 2-5 min at ≤15°C
- Best for
- Recovery
- Top biomarker
- Hscrp
- Literature
- Targeted literature base
- Coverage
- 3 graded signals
- Evidence grade
- B
- Linked biomarkers
- 3
- Tracked studies
- 38
Time-Restricted Eating
16:8 Intermittent Fasting Protocol
Circadian alignment strategy with consistent metabolic improvements independent of caloric restriction
Protocol signal
Daily / 8h eating window
- Best for
- Metabolic
- Top biomarker
- Fasting Glucose
- Literature
- Active literature base
- Coverage
- 5 graded signals
- Evidence grade
- B
- Linked biomarkers
- 5
- Tracked studies
- 95
Ashwagandha
Standardized root extract
Cortisol reduction · stress resilience · recovery support
Mechanism signal
HPA axis modulation — withanolides suppress CRH-driven ACTH secretion and attenuate cortisol output from adrenal cortex; adaptogenic normalization of glucocorticoid receptor sensitivity proposed via heat shock protein modulation
- Best for
- Hormonal
- Top biomarker
- Cortisol
- Literature
- Current through 2026
- Coverage
- 59 graded signals
- Evidence index
- 76
- Linked biomarkers
- 59
- Tracked studies
- 94
Taurine
Free amino acid
Osmotic regulation · cardiac function · recovery support
Mechanism signal
Cell volume regulation / osmolyte buffering
- Best for
- Cardiovascular
- Top biomarker
- AST
- Literature
- Current through 2026
- Coverage
- 74 graded signals
- Evidence index
- 71
- Linked biomarkers
- 74
- Tracked studies
- 386
Lion's Mane
Hericium Extract
NGF support, memory, and neuroprotection
Mechanism signal
NGF biosynthesis induction — hericenones (fruiting body) and erinacines A/C/E/F/G/S (mycelium) stimulate nerve growth factor synthesis in astrocytes and neuronal cells; downstream signaling via TrkA/Erk1/2 and PI3K-Akt pathways drives neurite outgrowth
- Best for
- Cognitive
- Top biomarker
- IL-6
- Literature
- Current through 2025
- Coverage
- 56 graded signals
- Evidence index
- 68
- Linked biomarkers
- 56
- Tracked studies
- 7
PQQ
Pyrroloquinoline Quinone
Mitochondrial biogenesis and neuroprotection
Mechanism signal
PGC-1α / mitochondrial biogenesis
- Best for
- Cognitive
- Top biomarker
- ALT
- Literature
- Current through 2025
- Coverage
- 56 graded signals
- Evidence index
- 62
- Linked biomarkers
- 56
- Tracked studies
- 16
Vitamin C
Structured dossier entry
Direct ROS scavenging — ascorbate donates electrons to neutralize superoxide, hydroxyl radicals, and peroxynitrite; oxidized to dehydroascorbic acid (DHA), which is recycled back to ascorbate via glutathione-dependent reductase, coupling vitamin C status to cellular glutathione pool
Mechanism signal
Direct ROS scavenging — ascorbate donates electrons to neutralize superoxide, hydroxyl radicals, and peroxynitrite; oxidized to dehydroascorbic acid (DHA), which is recycled back to ascorbate via glutathione-dependent reductase, coupling vitamin C status to cellular glutathione pool
- Best for
- Compound
- Top biomarker
- AST
- Literature
- Current through 2026
- Coverage
- 84 graded signals
- Dossier status
- Dossier live
- Linked biomarkers
- 84
- Tracked studies
- 925
Vitamin D3
Structured dossier entry
1,25-dihydroxyvitamin D3 binds VDR; VDR heterodimerises with RXR; complex translocates to nucleus and binds vitamin D response elements (VDREs) in promoter regions of >1000 target genes regulating calcium homeostasis, immune function, cell proliferation, and apoptosis
Mechanism signal
1,25-dihydroxyvitamin D3 binds VDR; VDR heterodimerises with RXR; complex translocates to nucleus and binds vitamin D response elements (VDREs) in promoter regions of >1000 target genes regulating calcium homeostasis, immune function, cell proliferation, and apoptosis
- Best for
- Compound
- Top biomarker
- AST
- Literature
- Current through 2026
- Coverage
- 97 graded signals
- Dossier status
- Dossier live
- Linked biomarkers
- 97
- Tracked studies
- 925